|
KMID : 0378120020290020001
|
|
Chungnam Medical Journal
2002 Volume.29 No. 2 p.1 ~ p.8
|
|
|
Matrix Metalloproteinase-3 in Atherogenesis in Rabbits
|
|
Lee Choong-Sik
Kim Su-Ryoung
Jung Su-Jin
Na Sun-Young
|
|
|
Abstract
|
|
|
|
A relation between atherogenesis and expression of a type of gelatinase, matrix metalloproteinase3 (MMP-3) was investigated in male New Zealand White Rabbits. Lesion development and immunohistochemical reaction for anti-MMP-3 were measured in the aorta. After 4 months of provocation of atherosclerosis with a hyperlipidemic diet, the rabbits were divided into a hyperlipidemic diet group, a normal diet group, and a hyperlipidemic plus phytoestrogen diet group. Normal feeding continued for an additional 4 months. Atherosclerotic lesions developed mildly during the provocation period (0.269mm^(2)). Lesion development progressed due to continuous hyperlipidemic diet (10.06mm^(2)) but was partly inhibited by phytoestrogen (0.997mm^(2)). A normal diet resulted in slight decrease in the lesion size (0.228mm^(2)). The immunohistochemistry for anti-MMP-3 showed a diffuse reaction along the endothelium and foamy cells within the lesion. The normal diet group revealed slight decrease the intensity compared to the other groups. Atherosclerosis induced by a hyperlipidemic diet can be inhibited by phytoestrogen in rabbits. A hyperlipidemic diet may stimulate MMP-3 in the aorta of rabbits.
|
|
|
KEYWORD
|
|
|
Atherosclerosis, Metalloproteinase3, New Zealand White Rabbits, Phytoestrogen
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|